Dendrimers: Risk Studies

Agashe, H.B., Dutta, T.D., Garg, M., Jain, N.K. (November 2006). Investigations on the toxicological profile of functionalized fifth-generation poly (propylene imine) dendrimer. Journal of Pharmacy and Pharmacology, 58(11):1491-8. Abstract [1].
Chen, H.-T., Neerman, M. F., Parrish, A. R., Simanek, E. E. (2004). Cytotoxicity, Hemolysis, and Acute in Vivo Toxicity of Dendrimers Based on Melamine, Candidate Vehicles for Drug Delivery. J. Am. Chem. Soc., 126(32): 10044-10048. Abstract [2].
- NEW - Cheng, Y. and T. Xu. (2010). The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs. European Journal of Medicinal Chemistry. 43(11): 2291-2297. Abstract [3]
Duncan, R. and Izzo, L. (December 2005). Dendrimer biocompatibility and toxicity. Advanced Drug Delivery Reviews, 57,15: 2215-2237. Abstract [4].
El-Sayed, M., Ginski, M., Rhodes, C., and Ghandeharia, H. (2002). Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers. Journal of Controlled Release, 81: 355–365. Abstract [5].
Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T. (March 2003). In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials, 24:1121–1131. Abstract [6].
- NEW - Jain, K., Kesharwani, P., Gupta, U., and N.K. Jain. (2010). Dendrimer toxicity: Let's meet the challenge. International Journal of Pharmaceutics. 394(1-2): 122-142. Abstract [7]
Jevprasesphant, R., Penny, J., Attwood, D., McKeown, N., D’Emanuele, A. (October 2003).
Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity. Pharmaceutical Research, 20,10: 1543-1550. Abstract [8].
Jevprasesphant, R., Penny, J., Jalal, R., Attwood, D., McKeown, N., D’Emanuele, A. (February 2003). The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int. J. Pharm., 1: 263–266. Abstract [9].
Jevprasesphant, R., Penny, J., Attwood, D., McKeown, N. B. D’Emanuele, A. (2003). Cytotoxicity and transepithelial transport of PAMAM dendrimers and dendrimer conjugates. Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 30, 146.
Jevprasesphant, R., Penny, J., Jalal, R., Attwood, D., McKeown, N. B. D’Emanuele, A. (2002). Investigation of the cytotoxicity of PAMAM dendrimers using a Caco-2 cell model. PharmSci., 4 (4), W5127, 2002.
Krishnaa, T.R., Jainb, S., Tatub, U.S., and Narayanaswamy, J. (April 2005). Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimersnext term. Tetrahedron, 61,17: 4281-4288. Abstract [10].
Kuo, JHS; Jan, MS; Lin, YL. (July 2007). Interactions between U-937 human macrophages and poly(propyleneimine) dendrimers. Journal of Controlled Release, 120(1-2): 51-59. Abstract [11].
Lesniak, W., Shi, X., Bielinska, B., Janczak, K., Sun, K., Baker, J.R., Balogh, L.P. (2005). Labeling Cells with Silver/Dendrimer Nanocomposites. Mater. Res. Soc. Symp. Proc. Vol. 845. Article [12].
Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J. W., Meijer, E. W., Paulus, W., and Duncan, R. (March 2000). Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125 I-labelled polyamidoamine dendrimers in vivo. Journal of Controlled Release, 65,1-2: 133-148. Abstract [13].
Najlah, M., Freeman, S., Attwood, D., and D’Emanuele, A. (2006). In vitro evaluation of dendrimer prodrugs for oral drug delivery. International Journal of Pharmaceutics. Abstract [14].
Nanomedicine website, information about dendrimers in medicine. Available at: Link [15].
Nigavekar, S., Sung, L. Y., Llanes, M., El-Jawahri, A., Lawrence, T. S., Christopher, W. B., Balogh, L., & Khan, M. (2004). 3H dendrimers nanoparticles organ/tumor distribution. Pharmaceutical Research, 21(3): 476-483.
Santhakumaran, L.M., Thomas, T. and Thomas, T.J. (2004). Enhanced cellular uptake of a triplex-forming oligonucleotide by nanoparticle formation in the presence of polypropylenimine dendrimers. Nucleic Acids Res., 32(7): 2102–2112. Abstract [16].
Wiwattanapatapee, R., Carreño-Gómez, B., Malik, N., and Duncan, R. (August 2000). Anionic PAMAM Dendrimers Rapidly Cross Adult Rat Intestine In Vitro: A Potential Oral Delivery System? Pharmaceutical Research, 17, 8: 991-998. Abstract [17].

Last updated July 2010- Maria Powell