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CCoN/NanoCEO's comments to the government

Dendrimers: Risk Studies

  • Agashe, H.B., Dutta, T.D., Garg, M., Jain, N.K. (November 2006). Investigations on the toxicological profile of functionalized fifth-generation poly (propylene imine) dendrimer. Journal of Pharmacy and Pharmacology, 58(11):1491-8. Abstract.
  • Chen, H.-T., Neerman, M. F., Parrish, A. R., Simanek, E. E. (2004). Cytotoxicity, Hemolysis, and Acute in Vivo Toxicity of Dendrimers Based on Melamine, Candidate Vehicles for Drug Delivery. J. Am. Chem. Soc., 126(32): 10044-10048. Abstract.
  • - NEW - Cheng, Y. and T. Xu. (2010). The effect of dendrimers on the pharmacodynamic and pharmacokinetic behaviors of non-covalently or covalently attached drugs. European Journal of Medicinal Chemistry. 43(11): 2291-2297. Abstract
  • Duncan, R. and Izzo, L. (December 2005). Dendrimer biocompatibility and toxicity. Advanced Drug Delivery Reviews, 57,15: 2215-2237. Abstract.
  • El-Sayed, M., Ginski, M., Rhodes, C., and Ghandeharia, H. (2002). Transepithelial transport of poly(amidoamine) dendrimers across Caco-2 cell monolayers. Journal of Controlled Release, 81: 355–365. Abstract.
  • Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T. (March 2003). In vitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials, 24:1121–1131. Abstract.
  • - NEW - Jain, K., Kesharwani, P., Gupta, U., and N.K. Jain. (2010). Dendrimer toxicity: Let's meet the challenge. International Journal of Pharmaceutics. 394(1-2): 122-142. Abstract
  • Jevprasesphant, R., Penny, J., Attwood, D., McKeown, N., D’Emanuele, A. (October 2003).
    Engineering of Dendrimer Surfaces to Enhance Transepithelial Transport and Reduce Cytotoxicity. Pharmaceutical Research, 20,10: 1543-1550. Abstract.
  • Jevprasesphant, R., Penny, J., Jalal, R., Attwood, D., McKeown, N., D’Emanuele, A. (February 2003). The influence of surface modification on the cytotoxicity of PAMAM dendrimers. Int. J. Pharm., 1: 263–266. Abstract.
  • Jevprasesphant, R., Penny, J., Attwood, D., McKeown, N. B. D’Emanuele, A. (2003). Cytotoxicity and transepithelial transport of PAMAM dendrimers and dendrimer conjugates. Proceed. Intern. Symp. Control. Rel. Bioact. Mater., 30, 146.
  • Jevprasesphant, R., Penny, J., Jalal, R., Attwood, D., McKeown, N. B. D’Emanuele, A. (2002). Investigation of the cytotoxicity of PAMAM dendrimers using a Caco-2 cell model. PharmSci., 4 (4), W5127, 2002.
  • Krishnaa, T.R., Jainb, S., Tatub, U.S., and Narayanaswamy, J. (April 2005). Synthesis and biological evaluation of 3-amino-propan-1-ol based poly(ether imine) dendrimersnext term. Tetrahedron, 61,17: 4281-4288. Abstract.
  • Kuo, JHS; Jan, MS; Lin, YL. (July 2007). Interactions between U-937 human macrophages and poly(propyleneimine) dendrimers. Journal of Controlled Release, 120(1-2): 51-59. Abstract.
  • Lesniak, W., Shi, X., Bielinska, B., Janczak, K., Sun, K., Baker, J.R., Balogh, L.P. (2005). Labeling Cells with Silver/Dendrimer Nanocomposites. Mater. Res. Soc. Symp. Proc. Vol. 845. Article.
  • Malik, N., Wiwattanapatapee, R., Klopsch, R., Lorenz, K., Frey, H., Weener, J. W., Meijer, E. W., Paulus, W., and Duncan, R. (March 2000). Dendrimers: Relationship between structure and biocompatibility in vitro, and preliminary studies on the biodistribution of 125 I-labelled polyamidoamine dendrimers in vivo. Journal of Controlled Release, 65,1-2: 133-148. Abstract.
  • Najlah, M., Freeman, S., Attwood, D., and D’Emanuele, A. (2006). In vitro evaluation of dendrimer prodrugs for oral drug delivery. International Journal of Pharmaceutics. Abstract.
  • Nanomedicine website, information about dendrimers in medicine. Available at: Link.
  • Nigavekar, S., Sung, L. Y., Llanes, M., El-Jawahri, A., Lawrence, T. S., Christopher, W. B., Balogh, L., & Khan, M. (2004). 3H dendrimers nanoparticles organ/tumor distribution. Pharmaceutical Research, 21(3): 476-483.
  • Santhakumaran, L.M., Thomas, T. and Thomas, T.J. (2004). Enhanced cellular uptake of a triplex-forming oligonucleotide by nanoparticle formation in the presence of polypropylenimine dendrimers. Nucleic Acids Res., 32(7): 2102–2112. Abstract.
  • Wiwattanapatapee, R., Carreño-Gómez, B., Malik, N., and Duncan, R. (August 2000). Anionic PAMAM Dendrimers Rapidly Cross Adult Rat Intestine In Vitro: A Potential Oral Delivery System? Pharmaceutical Research, 17, 8: 991-998. Abstract.

Last updated July 2010- Maria Powell

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