Risk Studies

• Ballou, B., Lagerholm, B. C., Ernst, L. A., Bruchez, M. P. & Waggoner, A. S. (2004). Noninvasive imaging of quantum dots in mice. Bioconjugate Chemistry, 15, 79-86.
• Derfus, A. M., Chan, W. C. W., Bhatia, S. N. 2003. Probing the cytotoxicity of semiconductor quantum dots. Nano Letters, 4(1), 11-18.
• Dubertret, B., Skourides, P., Norris, D. J., Noireaux, V., Brivanlou, A. H. & Libchaber, A. (2002). In vivo imagine of quantum dots encapsulated in phospholipid micelles. Science, 28(5599), 1759-1762.
• Green, M. & Howman, E. (2005). Semiconductor quantum dots and free radical induced DNA nicking. Chemical Communications, 1, 121-1213.
• Gagne, F.; Auclair, J.; Turcotte, P.; et al. (February 2008). Ecotoxicity of CdTe quantum dots to freshwater mussels: Impacts on immune system, oxidative stress and genotoxicity. Aquatic Toxicology, 86(3): 333-340.
• Gopee, N.V., Roberts, D.W., Webb, P. et al. (2007). Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice. Toxicological Sciences, 98(1):249-257. Abstract.
• - NEW - Gopee, N.V., Roberts, D.W., Webb, P. Cozart, C.R., Siitonen, P.H., Latendresse, J.R., Warbitton, A.R., Yu, W.W., Colvin, V.L., Walker, N.J., Howard, P.C.(2009). Quantitative determination of skin penetration of PEG-coated CdSe quantum dots in dermabraded but not intact SKH-1 hairless mouse skin. Toxicological Sciences, 11(1):37-48. Abstract.
• Guo, G.N., Liu, W., Liang, J.G., He, Z.K., Xu, H.B., Yang, X.L. (April 2007). Probing the cytotoxicity of CdSe quantum dots with surface modification. Material Letters, 61(8-9): 1641-1644. Abstract.
• Hardman, R. (2005). A toxicological review of quantum dots: Toxicity depends on physico-chemical and environmental factors. Environmental Health Perspectives, 114(2): 165-172.
  Article
• Holbrook, RD; Murphy, KE; Morrow, JB; Cole, KD. (June 2008). Trophic transfer of nanoparticles in a simplified invertebrate food web. Nature Nanotechnology, 3(6): 352-355. Abstract
• Hoshino, A., Hanaki, K., Suzuki, K., Yamamoto, K. (2004a). Applications of T-lymphoma labeled with fluorescent quantum dots to cell tracing markers in mouse body. Biochemical and Biophysical Research Communications, 314, 46-53.
• Hoshino, A., Fujioka, K., Oku, T., Suga, M., Sasaki, Y. F., Ohta, T., Hasuhara, M., Suzuki, K., & Yamamoto, K. (2004b). Physicochemical properties and cellular toxicity of nanocrystal quantum dots depend on their surface modification. Nano Letters, 4(11): 2163-2169.
• Jaiswal, J. K., Mattoussi, H., Mauro, J. M., Simon, S. M., (2003). Long-term multiple color imaging of live cells using quantum dot bioconjugates. Nature Biotechnology, 21, 47-51.
• Kennel, SJ; Woodward, JD; Rondinone, AJ; et al. (May 2008). The fate of MAb-targeted (CdTe)-Te-125m/ZnS nanoparticles in vivo. Nuclear medicine and biology, 35(4): 501-514. Abstract.
• Larson, D. R., Zipfel, W. R., Williams, R. M., Clark, S. W., Bruchez, M. P., Wise, F. W., et al. (2003). Water-soluble quantum dots for multiphoton fluorescence imaging in vivo. Science, 300(5624), 1434-1436.
• Li, HC; Zhou, QF; Liu, W; et al. (May 2008). Progress in the toxicological researches for quantum dots. Science in China Series B-Chemistry , 51(5): 393-400. Abstract.
• Linse, S., Cabaleiro-Lago, C., Xue, W.F.(May 2007). Nucleation of protein fibrillation by nanoparticles. Proceedings of the National Academy of Sciences of the United States of America, 104(21): 8691-8696. Article
• Lovrick, J., Bazzi, H.S., Cuie, Y., Fortin, G. R., Winnik, F. M. & Maysinger, D. (2005). Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. Journal of Molecular Medicine, 83, 377-385.
• Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan G., Wu, A. M., Gambhir, S. S. & Weiss, S. (2005). Quantum dots for live cells, in vivo imaging, and diagnostics. Science, 307, 538-544.
• Rouse, JG; Haslauer, CM; Loboa, EG, et al. (March 2008). Cyclic tensile strain increases interactions between human epidermal keratinocytes and quantum dot nanoparticles. Toxicol In Vitro, 22(2):491-7. Abstract.
• Rushton, E. K., Oberdorster, G., & Finkelstein, J. (2005). Nanoparticles are capable of producing reactive oxygen species, upregulation of inflammatory cytokine expression and causing increased cytotoxicity. Paper presented at the 2nd International Symposium on Nanotechnology and Occupational Health. Oct. 3-6, Minneapolis, MN.
• Ryman-Rasmussen, J.P., Riviere, J.E., and Monteiro-Riviere, N.A. (August 2006). Surface Coatings Determine Cytotoxicity and Irritation Potential of Quantum Dot Nanoparticles in Epidermal Keratinocytes. Journal of Investigative Dermatology, Abstract. Article
• Ryman-Rassmussen, j.r., Riviere, J.E. & Monteiro-Riviere, N.A. (2006). Penetration of intact skin by quantum dots with diverse physiochemical properties. Toxicological Sciences. Prepublication online. Abstract
• Shiohara, A., Hoshino, A., Hanaki, K., Suzuki, K. & Yamamoto, K. (2004). On the cyto-toxicity caused by quantum dots. Microbiology and Immunology, 48 (9), 669-675.
• Sweet, L., Strohm, B. (June 2006). Nanotechnology - Life-cycle risk management. Human and Ecological Risk Assessment, 12 (3): 528-551
• Tang, M., Xing, T., Zeng, J. et al. (July 2008). Unmodified CdSe Quantum Dots Induce Elevation of Cytoplasmic Calcium Levels and Impairment of Functional Properties of Sodium Channels in Rat Primary Cultured Hippocampal Neurons. Environmental Health Perspectives, 116(7): 915-922. Abstract.
• Voura, E. B., Jaiswal, J. K., Mattoussi, H., Simon, S. M. (2004). Tracking metastatic tumor cell extravasation with quantum dot nanocrystals and fluorescence emission-scanning microscopy. Nat. Med., 10, 993-998.
• Yacobi, NR; Phuleria, HC. et al. (December 2007). Nanoparticle effects on rat alveolar epithelial cell monolayer barrier properties. Toxicology in Vitro, 21(8): 1373-1381.
• Yang, R.S.H., Chang, L.Z., et al. (September 2007). Persistent Tissue Kinetics and Redistribution of Nanoparticles, Quantum Dot 705, in Mice: ICP-MS Quantitative Assessment. Environmental Health Perspectives, 115(9): 1339-1343. Abstract.
• Zhang LW, Monteiro-Riviere NA. (June 2008). Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin. Skin Pharmacology and Physiology, 21(3):166-80. Abstract.
• Zhang LW, Yu WW, Colvin VL, Monteiro-Riviere NA. (April 2008). Biological interactions of quantum dot nanoparticles in skin and in human epidermal keratinocytes. Toxicol Appl Pharmacol., 228(2):200-11. Abstract.
• Zhang, TT; Stilwell, JL; Gerion, D; Ding, LH; Elboudwarej, O; Cooke, PA; Gray, JW; Alivisatos, AP; Chen, FF (April 2006). Cellular effect of high doses of silica-coated quantum dot profiled with high throughput gene expression analysis and high content cellomics measurements. Nano Letters, 6 (4): 800-808. Abstract. Article
• Zhang, Y., Chen, W., Zhang, J., Liu, J., Chen, G., Pope, C. (February 2007). In Vitro and In Vivo Toxicity of CdTe Nanoparticles. Journal of Nanoscience and Nanotechnology 7,2: 497-503
• Zhang, T., Stilwell, J.L. et al. (2006). Cellular Effect of High Doses of Silica-Coated Quantum Dot Profiled with High Throughput Gene Expression Analysis and High Content Cellomics Measurements. Nano Lett., 6 (4): 800-808. Abstract

Last updated January 2010 - Maria Powell